CALL FOR PAPERS Cell and Molecular Processes in Cancer Metastasis Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis
نویسندگان
چکیده
Abdo J. Najy, Gregory Dyson, Bhanu P. Jena, Chen-Yong Lin, and Hyeong-Reh C. Kim Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan; Department of Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan; Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan; and Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia
منابع مشابه
Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis.
Activation of β-platelet-derived growth factor receptor (β-PDGFR) is associated with prostate cancer (PCa) progression and recurrence after prostatectomy. Analysis of the β-PDGFR ligands in PCa revealed association between PDGF-D expression and Gleason score as well as tumor stage. During the course of studying the functional consequences of PDGF ligand-specific β-PDGFR signaling in PCa, we dis...
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The platelet-derived growth factors (PDGF A, B, C, and D) and their receptors (a-PDGFR and b-PDGFR) play an indispensible role in physiologic and pathologic conditions, including tumorigenesis. The transformative b-PDGFR is overexpressed and activated during prostate cancer progression, but the identification and functional significance of its complementary ligand have not been elucidated. This...
متن کاملMatriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity
The type 2 transmembrane serine protease matriptase is involved in many pathophysiological processes probably via its enzymatic activity, which depends on the dynamic relationship between zymogen activation and protease inhibition. Matriptase shedding can prolong the life of enzymatically active matriptase and increase accessibility to substrates. We show here that matriptase shedding occurs vi...
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